| July 6, 2008 |
Welcome reception and buffet dinner
in the Portland Room,
hosted by Professor Waqar Ahmad,
Assistant Vice-Chancellor
and Director, Middlesex Research. |
| |
| Day 1 - July 7, 2008 |
| Gonadotropins and Cancer |
| Chair: Prof. Michael Seckl and Dr. Peter Delves |
| 9:00 - 9:15 |
Welcome |
| 9:15 - 9:45 |
Prof. Ray Iles (UK) |
Does hCG play any role in cancer cell biology? |
| 9:45 - 10:15 |
Dr. Irma Russo (USA) |
Use of hCG in the Prevention of Breast Cancer in Young Nulliparous Women |
| 10:15 - 10:45 |
Dr. Peter Leung (Canada) |
Gonadotropins and ovarian cancer growth and invasion |
| 10:45 - 11:15 |
Refreshments |
| 11:15 - 11:45 |
Prof. Ilpo Huhtaniemi (UK) |
Genetically modified mice and gonadotropin dependent tumours |
| 11:45 - 12:15 |
Prof. Michael Seckl (UK) |
The role of hCG monitoring in patients with gestational trophoblastic neoplasia (GTN): the importance of false negatives |
| 12:15 - 12:30 |
Abstract number 1.1
- Dr. Tom Hopp (USA) |
Preclinical characterization of CG201, a new more potent anti-hCG cancer vaccine formulation |
| 12:30 - 12:45 |
Abstract number 1.2
- Dr. Anna Jankowska (Poland) |
Silencing of human chorionic gonadotropin beta subumit expression induce apoptosis in cervical cancer cells |
| 12:45 - 14:30 |
Lunch & Poster Session I |
Recent Progress in Gonadotropin Analysis
Sponsored by the UK National External Quality Assessment Service (UK NEQAS) |
| Chair: Dr. Cathie Sturgeon and Dr. Andrew Kicman |
| 14:30 - 15:15 |
Dr. Cathie Sturgeon (UK) |
Gonadotropin Standards – Achievements and challenges for the future |
| 15:15 - 16:00 |
Prof. David Handelsman (Australia) |
Detection of recombinant human luteinizing hormone and human chorionic gonadotropin doping in men |
| 16:00 - 16:30 |
Refreshments |
| 16:30 - 17:00 |
Dr. Peter Berger (Austria) |
Antigenic mapping of hCG - what are we measuring? |
| 17:00 - 17:30 |
Dr. Ulf-Hakan Stenman (Finland) |
Molecular & structural variant specific detection of HCG – does it matter? |
| 17:30 - 17:45 |
Abstract number 1.3
- Prof. Richard Bayford (UK) |
Electrochemical impedance detection of hCGB: Preliminary results and analysis in the development of 'lab on a chip' technology |
| 17:45 - 18:00 |
Award Presentation by Cathie Sturgeon (UK) |
Dr. Steven Birkin |
| Close |
| |
| Day 2 - July 8, 2008 |
| Gonadotropin Genetics & Function |
| Chair: Prof. Ilpo Huhtaniemi and Prof. Maris Laan |
| 9:00 - 9:30 |
Prof. Maris Laan (Estonia) |
Human gonadotropin genes: genetic variation and comparison to our sister-species, common chimpanzee |
| 9:30 - 10:00 |
Dr. Jan Bogerd (Netherlands) |
Evolution of gonadotropin receptor gene |
| 10:00 - 10:15 |
Abstract number 2.1
- Dr. Nico Schoemaker (Netherlands) |
The role of the full length and splice variant of the ferret LHR in the etiology of spontaneous hyperadrenocorticism in ferrets |
| 10:15 - 10:45 |
Refreshments |
| 10:45 - 11:15 |
Dr. K. M. J. Menon (USA) |
Molecular regulation of gonadotropin receptor expression: Relationship to sterol metabolism |
| 11:15 - 11:45 |
Dr. C. V. Rao (USA) |
Human adrenal LH/hCG receptors and what they could mean for adrenal physiology and pathology |
| 11:45 - 12:15 |
Dr. M Ram Sairam (Canada) |
Chronology and complexity of ovarian tumorigenesis in forko mice |
| 12:15 - 12:30 |
Abstract number 2.2
- Dr. Hellevi Peltoketo (UK) |
Consequences of constitutively active Fshr: follicle loss, germ cell tumors and pituritary, mammary gland and adrenal hyperplasia |
| 12:30 - 12:45 |
Abstract number 2.3
- Liis Uuskula (Estonia) |
Do epigenetic modifications of hCG beta coding genes contribute to pregnancy success? |
| 12:45 - 14:30 |
Lunch & Poster Session II |
| Receptors - Structure & Function |
| Chair: Dr. J. David Puett and Dr. James Dias |
| 14:30 - 15:00 |
Prof. J. David Puett (USA) |
LHR structure function and putative role in ovarian cancer |
| 15:00 - 15:30 |
Dr. James Dias (USA) |
Effects of modifying FSH Receptor adapter protein interaction domains on FSH signaling |
| 15:30 - 16:00 |
Dr. Sabine Costagliola (Belgium) |
Inverse Relation between constitutive activity and negative cooperativity in mutants of glycoprotein hormone receptors |
| 16:00 - 16:30 |
Refreshments |
| 16:30 - 17:00 |
Dr. Alfredo Ulloa-Aguirre (Mexico) |
Dominant negative effects of human follicle-stimulating hormone receptor mutants on wild type receptor expression |
| 17:00 - 17:30 |
Prof. Rajan Dighe (India) |
Elucidating Gonadotropins-receptors interactions using hormone analogues and specific antibodies
|
| 17:30 - 17:45 |
Abstract number 2.4
- Astrid Musnier (France) |
Developmentally regulated integration of PKA-and PI-3 kinase-mediated signalling on p70S6K by the FSH-R |
| 17:45 - 18:00 |
Abstract number 2.5
- Madhavi Dupakuntla (India) |
Charged amino acids in the peptide 20-30 of FSHR contribute to the FSH antagonistic activity |
| Close |
| |
| Day 3 - July 9, 2008 |
| New developments in Gonadotropin Biology and Pharmacology |
| Prof Peter Berger & Prof Ulf Hakan Stenman |
| 9:00 - 9:30 |
Prof. Eef Hogervorst (UK) |
Gonadotropin and testosterone levels in dementia |
| 9:30 - 10:00 |
Dr. Mone Zaidi (USA) |
The pituitary-bone axis |
| 10:00 - 10:15 |
Abstract number 3.1
- Dr. Stella Campo (Argentina) |
Effect of sialylation and complexity of FSH oligosaccharides on inhibin production by rat granulosa cells |
| 10:15 - 10:30 |
Abstract number 3.2
- Guillaume Durand (France) |
Selective B-arrestin-dependent signalling by FSHR mutants |
| 10:30 - 11:00 |
Refreshments |
| 11:00 - 11:15 |
Abstract number 3.3
- Vanessa Wehbi (France) |
Impact of eCG/anti-eCG antibodies copmplexes on the signalling pathways induced by FSHR |
| 11:15 - 11:30 |
Abstract number 3.4
- Ankita Shah (UK) |
The effects of CodeBreaker™ Silencing of CGB Genes on Bladder Cancer Cell Line viability |
| 11:30 - 12:15 |
Prof. Laurence Cole (USA) |
hCG and hyperglycosylated hCG in hermchorial implantation: 1. parallel evolution |
| 12:15 - 14:00 |
Lunch & Poster Session III |
| Gonadotropins & Reproductive Biology |
| Chair: Prof. Ray Iles and Dr. Stephen Butler |
| 14:00 - 14:30 |
Dr. Peter Delves (UK) |
Immunological Contraception: Can Gonadotropins Still Be Considered Viable Candidates for Anti-Fertility Vaccines? |
| 14:30 - 15:00 |
Dr. Stephen Butler (UK) |
Perspectives on the monitoring and clinical utility of hCG measurement in the diagnosis of ectopic pregnancy |
| 15:00 - 15:15 |
Abstract number 3.
- Dr. Thierry Fournier (France) |
hCG from invasive extravillous cytotrophoblast but not from synctiotrophoblast origin stimulates trophoblast invation in vitro |
| 15:15 - 15:45 |
Refreshments |
| 15:45 - 16:15 |
Prof. Marek Zygmunt (Germany) |
Gonadotropins and angiogenesis |
| 16:15 - 16:30 |
Abstract number 3.6
- Dr. Kristiina Rull (Estonia) |
Human chorionic gonadotropin beta genes: expression, genetic variation and reproductive failure |
| 16:30 - 17:30 |
Lord Robert Winston (UK) |
From Stem Cells to New Fertility Therapies? |
| Close |
